[简介]

赵玉华：女，博士，教授，硕士生导师。2012年第三届美中抗癌协会(USCACA)/亚洲癌症研究基金会(AFCR)优秀学者奖获得者。四川省学术和技术带头人后备人选。1988-1995年就读于华西医科大学药学院，相继获理学学士和硕士学位。毕业后在澳门尼威斯人网站8311基础医学与法医学院生物化学与分子生物学教研室从事教学和科研工作。2003年获澳门尼威斯人网站8311生物化学与分子生物学理学博士学位。2006年受纽约中华医学基金会(CMB)资助赴美国肯塔基大学做访问学者，2007年至2010年在美国南阿拉巴马大学米歇尔肿瘤研究所作博士后研究。现负责国家自然科学基金面上项目1项，教育部留学回国人员科研启动基金1项；作为主研参与国家自然科学基金2项，省科技厅项目1项，协作项目3项。已在国内外期刊发表论文30多篇，其中SCI论文15篇，累计影响因子达77。代表性论文发表在Cancer Res，Oncogene, Nat Commun，J Bio Chem, Cell Death Dis, Mol Cancer Ther等期刊。中国生物化学与分子生物学会会员，美国癌症研究协会(AACR)会员，国际英文期刊SCI REP, PLoS ONE，JECCR，ONCOL LETT等审稿人。

[研究方向]

1. 代谢与肿瘤

2. MicroRNA与肿瘤

3. LncRNA与肿瘤

4. 肿瘤治疗耐药性的分子机制与克服

[招生方向]

1. 生物化学与分子生物学：肿瘤分子细胞生物学与临床前应用研究

2. 医学生物化学与分子生物学：肿瘤分子细胞生物学与临床前应用研究

[代表性论著]

1. Butler EB，Zhao Y, Mu?oz-Pinedo C, Lu J, Tan M. Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance.Cancer Res, 2013, 73(9): 2709-17. (IF=8.65，被引32次)

2. Ding Y, Liu Z, Desai S,Zhao Y, Liu H, Pannell LK, Yi H, Wright ER, Owen LB, Dean-Colomb W, Fodstad O, Lu J, LeDoux SP, Wilson GL, Tan M. Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism.Nat Commun2012, 3: 1271. (IF=10.015)

3. Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics.Cell Death Dis2013，4e: 532 (IF=5.333，被引192次)

4. Zhao Y,Liu H, Liu Z, Ding Y, LeDoux SP, Wilson GL, Voellmy R, Lin Y, Lin W, Nahta R, Liu B, Fodstad O, Chen J, Wu Y, Price JE, and Tan M. Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.Cancer Res, 2011, 71(13); 4585-97.(IF = 7.856，被引69次).Featured on the homepage ofCancer Research, and featured in Nature/SciBX: Science-Business exchangeSciBX4(18); doi:10.1038/scibx.2011.505

5. Liu H, Tekle C, ChenYW,Kristian A,ZhaoYH, ZhouM, Liu ZX, Ding Y, Wang B, M?landsmo GM, Fodstad O, Tan M. B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.Mol Cancer Ther, 2011, 10(6):960-71.(IF= 5.226，被引30次)

6. Zhao Y, Liu H, Riker AI, Fodstad O, Ledoux SP, Wilson GL, Tan M. Emerging metabolic targets in cancer therapy.Front Biosci,2011, 16:1844-1860.(IF= 3.52)

7. Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, Fodstad O, Tan M.Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene,2009, 28(42): 3689-3701. (IF= 7.135，被引68次)Featured on the cover of the journal and in the USA news release and local news media.

8. Zhao Y*,Zhou M*, Ding Y*, Liu H, Liu Z, Fodstad O, Riker AI,Kamarajugadda S, Lu J, Owen LB, Ledoux SP, Tan M. Inhibition of lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol.Mol Cancer, 2010, 9(1):33. (*co-1^stauthors) (IF=3.779，被引94次)(*Marked “Highly Accessed” and ranked as “No.1 Most Accessed Paper” in the past 30 days and “Top 10 Most Accessed Paper” in the past year by the journal).

9. Zhou M, Liu Z,Zhao Y, Ding Y, Liu H, Xi Y, Xiong W, Li G, Lu J, Fodstad O, Riker AI, Tan M. MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic BCL-2 antagonist killer 1 (BAK1) expression.J Biol Chem,2010, 285(28):21496-21507. (IF=5.328，被引用183次)

10.Zhao Y, Weng CC, Tong M, Wei J, Tai HH. Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.Lung Cancer. 2010, 68(2): 161-169 (IF=3.356)

[联系方式]

四川省成都市人民南路3段17号

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生物化学与分子生物学教研室

邮编：610041

Tel：13709037270 E-mail:zhaoyh@scu.edu.cn