岳利民教授、博士生导师

澳门尼威斯人网站8311，澳门尼威斯人网站8311，生理学教研室

地址：四川成都人民南路三段17号，澳门尼威斯人网站8311，华西医学中心，生理学教研室

电话：028-85501276

Email：yuelimin@scu.edu.cn

1982年毕业于原华西医科大学医学系，获医学学士，留校后先后在职攻读并获得医学硕士和理学博士学位。2002.10-2003.12在美国University of Texas at Dallas和Vanderbilt University生殖生物学实验室作访问学者。

现任中国生理学会常务理事，中国生理学会教学工作委员会副主任，中国生理学会生殖科学专业委员会委员；四川省生理科学会生理学专委会副主任；澳门尼威斯人网站8311华西医学中心生理学教研室主任；中国生理学会刊物《生理学报》编委，《四川生理科学杂志》副主编。先后被评为四川省有突出贡献优秀专家，四川省卫生厅学术技术带头人，澳门尼威斯人网站8311教学名师和澳门尼威斯人网站8311唐立新教学名师等。

从事生殖医学领域科学研究30多年，对受精与着床的分子机制，性激素作用的分子机制，不育不孕及流产的病因、诊断及治疗有深入的研究。先后主持4项国家自然科学基金项目和多项四川省科研及教学项目。在国内、外杂志发表研究论文40多篇。主编人民卫生出版社十二五国家级规划教材教材2部（解剖生理学底5版和第6版），主编北京科学出版社教材1部（生理学），参译北京科学出版社生理学教材1部（医学生理学），参编高等教育出版社国家级规划教材2部（生理学、妇产科学）和研究生教材一部（生理科学进展）。

近年发表的代表论著：

1.Zhang SM, Yu LL, Qu T, Hu Y, Yuan DZ, Zhang S, Xu Q, Zhao YB, Zhang JH,Yue LM.The Changes of Cytoskeletal Proteins Induced by the Fast Effect of Estrogen in Mouse Blastocysts and Its Roles in Implantation. Reprod Sci.2017,24(12):1639-1646

2.Zhang S, Gao X, Fu W, Li S,Yue L. Immunoglobulin-like domain 4-mediated ligand-independent dimerization triggers VEGFR-2 activation in HUVECs and VEGFR2-positive breast cancer cells. Breast Cancer Res Treat 2017,163(3):423-434

3.Nie L, Zhao YB, Pan JL, Lei Y, Liu M, Long Y, Zhang JH, Hu Y, Xu MQ, Yuan DZ,Yue LM.Progesterone-Induced miR-152 Inhibits the Proliferation of Endometrial Epithelial Cells by Downregulating WNT-1. Reprod Sci.2017,24(10):1444-1453.

4.Pan JL, Yuan DZ, Zhao YB, Nie L, Lei Y, Liu M, Long Y, Zhang JH, Blok LJ, Burger CW,Yue LM.. Progesterone-induced miR-133a Inhibits the Proliferation of Endometrial Epithelial Cells. Acta Physiol (Oxf).2016.219(3):683-692

5.Qu T, Zhang SM, Yu LL, Zhang S, Yuan DZ, Xu Q, Zhang JH, He YP,Yue LM. Relocalisation and activation of integrins induced rapidly by oestrogen via G-protein-coupled receptor 30 in mouse blastocysts. Reprod Fertil2015 May 8. doi: 10.1071/RD14227

6.Yuan DZ; Yu LL; Qu T; Zhang SM; Zhao YB; Pan JL; Xu Q; He YP; Zhang JH;Yue LM. Identification and characterization of progesterone- and estrogen-regulated microRNAs in mouse.Reproductive Sciences, 2015, 22(2):223-234

7.Yu LL; Qu T; Zhang SM; Yuan DZ; Xu Q; Zhang JH; He YP;Yue LM.GPR30 mediates the fast effect of estrogen on mouse blastocyst and its role in implantation.Reproductive Sciences, 2015.22(10):1312-1320.

8.Yuan DZ,Ding XL,Yu HL,Cheng Z,Tang XR,He YP,Zhang JH,Blok LJ,Hanifi-Moghaddam P,Burger CW,Yue LM. Progesterone-induced cyclin G1 inhibits the proliferation of endometrial epithelial cell and its possible molecular mechanism.Hormone and Metabolic Research. 2014, 46(11):761-767.

9.Liu F,Gao XP,Yu HL,Yuan DZ,Zhang JH,He YP,Yue LM.Expression of exogenous cyclin G1 in human endometrial carcinoma cells and its effect on their proliferation.Chinese Journal of Physiology (CJP). 2013,56(2): 83-89

10.Liu F,Gao XP,Yu HL,Yuan DZ,Zhang JH,He YP,Yue LM.The role of progesterone and its receptor on cyclin G1 expression in endometrial carcinoma cells.Reproductive Sciences. 2012,19(11): 1205-1210

11.Lin-lin Yu, Jin-hu Zhang, Ya-ping He, Ping Huang, andLi-min Yue. Fast action of estrogen on intracellular calcium in mouse dormant blastocyst and its possible mechanism. Fertility and Sterility,2009,91(2): 611-615

13.Limin Yue, Takiko Daikoku, Xiaonan Hou, Meiling Li, Haibin Wang, Hiroshi Nojima, Sudhansu K. Dey, and Sanjoy K. Das. Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: Evidence for aberrant regulation with Hoxa-10 deficiency. Endocrinology,2005,146(5): 2424-2433

14.Yue Limin,Zhang Lei, He Yaping, Zhang Jinhu, Zheng Jie, He Yanfang, Zheng Yu, Zhang Jie & Zhang Li. Reorganization of cytoskeletal proteins of mouse oocytes mediated by integrins. Science in China Ser: C Life Sciences,2004,47(6): 540-544

15.Sang Yoon Han, Wen Sheng Xie, Sok Ho Kim,Limin Yue, and Jeff DeJong. A short core promoter drives expression of theALF transcription factor in reproductive tissues of male and female mice. Biology of Reproduction, 71(5): 933-941

16.于海礼，方明，袁东智，刘芳，徐倩，张金虎，何亚萍，岳利民。蛋白磷酸酶2A参与孕激素对子宫内膜上皮细胞增殖的负调控作用。澳门尼威斯人网站8311学报（医学版），43(2)：166-169

17.袁东智，于海礼，丁小玲，张金虎，何亚平，岳利民。周期素cyclin G1在小鼠睾丸生精上皮中的表达特点。澳门尼威斯人网站8311学报（医学版），42(4)：567-569

18.程钊，汤晓蓉，郄明蓉，张金虎，岳利民。人子宫内膜上皮视网膜母细胞瘤抑癌蛋白磷酸化状态及其与细胞周期蛋白G1的相关性。中国全科医学。2009，12(7B): 1290-2，1295

19.田吉梅，杨开选，白玛康卓，张金虎，何亚平，岳利民。CyclinG1的异常表达与子宫内膜癌发生的关系。生殖与避孕，2008，226(4)：226-231

20.马琰岩，范轶，白玛康卓，张金虎，何亚萍，喻琳鳞，岳利民。孕激素诱导cyclin G1在小鼠子宫内膜上皮细胞的表达及其对细胞增殖的影响。生理学报，60(4): 541-546

21.白玛康卓，田吉梅，杨开选，郄明蓉，张金虎，何亚平，岳利民。Cyclin G1 在正常月经周期人子宫内膜表达的周期性变化。澳门尼威斯人网站8311学报（医学版），39(4)：623-626

22.喻琳麟，胡颖，张金虎，何亚平，岳利民。17β-雌二醇快速诱导静止状态小鼠囊胚细胞胞内钙离子增加。细胞生物学杂志，2007，29(4): 569-572

23.柳朝华，张惠，何亚平，张金虎，岳利民。Cyclin G1在小鼠卵巢的表达及其与卵泡发育的关系。澳门尼威斯人网站8311学报·医学版，2006，37(6): 893-897

24.何彦芳，岳利民，何亚平，张金虎，郑洁，高小平。17β-雌二醇诱导人精子顶体反应率和胞内钙离子浓度升高的研究。澳门尼威斯人网站8311学报·医学版，2005，36(4): 500-502

25.郑洁，何亚平，张金虎，何彦芳，高小平，岳利民。人精子中芳香化酶表达与精子功能的关系。生殖与避孕，2005，25(3): 284-289

26.岳利民，张蕾，何亚平，张金虎，郑煜，黄萍，王丽，刘伟信。整合素α₅、α₆、β₁在人、小鼠卵的表达及其与卵成熟的关系。生殖与避孕，2004，24(3): 135-138

27.岳利民，张蕾，何亚平，张金虎，谢怡敏，郑煜，张立，黄萍，王丽，刘伟信。整合素介导小鼠卵内钙离子增加。生理学报，2004，56(3)：269-274

28.谢怡敏，岳利民，何亚平，张金虎，毛咏秋，雷松，郑煜。整合素VLA-5介导人精子激活作用的研究。澳门尼威斯人网站8311学报·医学版，2003，34(3): 459-461

29.张蕾，岳利民，张金虎，何亚平，郑煜，黄萍，王丽，刘伟信。整合素亚基α₅、β₁在人精子的表达及其与受精的关系。生殖与避孕，2002，22(2): 70-73

30.岳利民，张金虎，何亚平，黄萍，王丽，刘伟信，张蕾。人精子穿透去透明带金黄地鼠卵试验与人精卵体外受精的比较。华西医科大学学报，2001，32(1): 98-100

31.岳利民，何亚平，张金虎，雷松，黄萍，王丽，刘伟信，R ichard A. B ronson。整合素配体玻连蛋白在人精子的表达及受精中的作用。生殖与避孕，2001，21(1): 24-28

32.岳利民，何亚平，张金虎。磷酸二酯酶抑制剂己酮可可碱对人精子受精力的影响。华西医科大学学报，2000，31(4): 473 -4，505

Yue Limin M.D., Ph.D.

Professor

Department of Physiology

West China School of Basic Medical Sciences & Forensic Medicine,

Sichuan University

Address：

No.17 the 3rd section of South People Road, Chengdu, Sichuan Province

Phone Number : 028-85501276

Email: yuelimin@scu.edu.cn

Education

9/1999-6/2002 ,  Ph.D of  Physiology, Sichuan University, China

9/1984-9/1987,   Master of Medical Sciences, West China University of Medical Sciences,  China

3/1978-12/1982 , Bachelor of Medical Sciences ,West China University of Medical Sciences, China

Working experiences

12/1982-at present, Tearching of physiology and research of reproductive physiology, West China University of Medical Sciences and Sichuan University(at present)

3/2003-12/2003, Visiting Scholar,Division of Reproductive and Developemental biology, Department of Pediatrics, Vanderbilt University Medical Center,U.S.

10/2002-3/2003, Visiting Scholar，  Molecular and cell biology   Department  of molecular and cell biology，University of Texas,U.S.

Research interests:

1.The exression of progesteron dependent cyclin G1 and its roles in endometrial epithelial cells

 2.The fast activation of estrogen on mouse blastocyct and its signaling pathway

 3. Progesteron-induced MicroRNA inhibit the preliferation of endometrial epithelial cells

4.The role of PCSK9 in lipid metabolism and ovarian dysfunction in polycystic ovary syndrome and its mechanism

5, Identification of glucose transporters in endometrial epithelium and their roles in early embryonic devolopment and implantation.

Main Publications:

1. Zhang SM, Yu LL, Qu T, Hu Y, Yuan DZ, Zhang S, Xu Q, Zhao YB, Zhang JH, Yue LM. The Changes of Cytoskeletal Proteins Induced by the Fast Effect of Estrogen in Mouse Blastocysts and Its Roles in Implantation. Reprod Sci. 2017, 24(12):1639-1646

2. Zhang S, Gao X, Fu W, Li S, Yue L. Immunoglobulin-like domain 4-mediated ligand-independent dimerization triggers VEGFR-2 activation in HUVECs and VEGFR2-positive breast cancer cells. Breast Cancer Res Treat 2017,163(3):423-434

3. Nie L, Zhao YB, Pan JL, Lei Y, Liu M, Long Y, Zhang JH, Hu Y, Xu MQ, Yuan DZ, Yue LM. Progesterone-Induced miR-152 Inhibits the Proliferation of Endometrial Epithelial Cells by Down regulating WNT-1. Reprod Sci . 2017, 24(10):1444-1453.

4. Pan JL, Yuan DZ, Zhao YB, Nie L, Lei Y, Liu M, Long Y, Zhang JH, Blok LJ, Burger CW, Yue LM.. Progesterone-induced miR-133a Inhibits the Proliferation of Endometrial Epithelial Cells. Acta Physiol (Oxf) . 2016. 219(3):683-692

5. Qu T, Zhang SM, Yu LL, Zhang S, Yuan DZ, Xu Q, Zhang JH, He YP, Yue LM. Relocalisation and activation of integrins induced rapidly by oestrogen via G-protein-coupled receptor 30 in mouse blastocysts. Reprod Fertil 2015 May 8. doi: 10.1071/RD14227

6. Yuan DZ; Yu LL; Qu T; Zhang SM; Zhao YB; Pan JL; Xu Q; He YP; Zhang JH; Yue LM. Identification and characterization of progesterone- and estrogen-regulated microRNAs in mouse. Reproductive Sciences, 2015, 22(2): 223-234

7. Yu LL; Qu T; Zhang SM; Yuan DZ; Xu Q; Zhang JH; He YP; Yue LM. GPR30 mediates the fast effect of estrogen on mouse blastocyst and its role in implantation. Reproductive Sciences, 2015. 22(10):1312-1320.

8. Yuan DZ, Ding XL, Yu HL, Cheng Z, Tang XR, He YP, Zhang JH, Blok LJ, Hanifi-Moghaddam P, Burger CW, Yue LM. Progesterone-induced cyclin G1 inhibits the proliferation of endometrial epithelial cell and its possible molecular mechanism. Hormone and Metabolic Research. 2014, 46 (11): 761-767.

9. Liu F, Gao XP, Yu HL, Yuan DZ, Zhang JH, He YP, Yue LM. Expression of exogenous cyclin G1 in human endometrial carcinoma cells and its effect on their proliferation. Chinese Journal of Physiology (CJP). 2013, 56(2): 83-89

10. Liu F, Gao XP, Yu HL, Yuan DZ, Zhang JH, He YP, Yue LM. The role of progesterone and its receptor on cyclin G1 expression in endometrial carcinoma cells. Reproductive Sciences. 2012, 19(11): 1205-1210

11. Lin-lin Yu, Jin-hu Zhang, Ya-ping He, Ping Huang, and Li-min Yue. Fast action of estrogen on intracellular calcium in mouse dormant blastocyst and its possible mechanism. Fertility and Sterility, 2009, 91(2): 611-615

13. Limin Yue, Takiko Daikoku, Xiaonan Hou, Meiling Li, Haibin Wang, Hiroshi Nojima, Sudhansu K. Dey, and Sanjoy K. Das. Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: Evidence for aberrant regulation with Hoxa-10 deficiency. Endocrinology, 2005, 146(5): 2424-2433

14. Yue Limin, Zhang Lei, He Yaping, Zhang Jinhu, Zheng Jie, He Yanfang, Zheng Yu, Zhang Jie & Zhang Li. Reorganization of cytoskeletal proteins of mouse oocytes mediated by integrins. Science in China Ser: C Life Sciences, 2004, 47(6): 540-544