教授

98858vip威尼斯下载病理生理学教研室

通讯地址：

四川省成都市人民南路三段17号澳门尼威斯人网站8311华西校区基础医学与法医学院，病理生理学教研室

Email: huangpanxiao@sina.com

黄宁教授，医学博士，博士生导师。中国病理生理学会理事，中国病理生理学会炎症发热感染低温专业委员会副主任委员。四川省生理科学会理事长。四川省学术与技术带头人，四川省有突出贡献专家，四川省卫生厅学术与技术带头人，四川省病理生理学精品课程的负责人。澳门尼威斯人网站8311国家“理科基础科学研究和教学人才培养基地”（基础医学）及211重点学科建设学术带头人之一。病理生理教研室主任。曾任98858vip威尼斯下载副院长，CMB细胞分子病理生理学重点学科负责人，澳门尼威斯人网站8311“985”工程创新药物平台骨干。负责和主研过国家自然科学基金及CMB国际合作科研10余项，主编和参编专著教材7部，国内外发表科研论文100余篇，获四川省科技进步二等奖、国家发明专利各1项。澳门尼威斯人网站8311学报（医学版）、中国病理生理学杂志、中国抗生素杂志现编委。

教育及工作经历：

1985年毕业于华西医科大学临床医学系，留校任教至今。先后获得医学硕士学位和医学博士学位，并先后晋升为讲师、副教授和教授。

研究领域：

天然免疫与炎症基因调控和分子信号；药物靶点及信号通路；天然免疫的表观遗传学调控机制；天然免疫与人类重大疾病。

代表作：

1.Liu K, Wang X, Sha K, et al. Nuclear protein HMGN2 attenuates pyocyanin-induced

oxidative stress via Nrf2 signaling and inhibits Pseudomonas aeruginosa internalization in A549 cells. Free Radic Bio Med. 2017; 108:404-417.

2.Xu Q, Liu X, Wang X, et al. Growth arrest-specific protein 7 regulates the murine

M1 alveolar macrophage polarization. Immunol Res. 2017; 65(5):1065-1073.

3.Li H, Shen X, Zhou X, et al. Antibacterial mechanism of high-mobility group

nucleosomal-binding domain 2 on the Gram-negative bacteria Escherichia coli.

J Zhejiang Univ Sci B. 2017; 18(5):410-420.

4.Teng Y, Miao J, Shen X,et al. The modulation of MiR-155 and MiR-23a manipulates Klebsiella pneumoniae Adhesion on Human pulmonary Epithelial cells via Integrin α5β1 Signaling. Sci Rep. 2016; 6:31918.

5.Shen X, Teng Y, Sha K, et al. Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder. Biofactors. 2016; 42(6):674-685.

6.Yang X, Sha K, Xu G, et al. Subinhibitory Concentrations of Allicin Decrease

UropathogenicEscherichia coli(UPEC) Biofilm Formation, Adhesion Ability, and

Swimming Motility. Int J Mol Sci. 2016; 17(7):979.

7.Wang X, Li J, Chen S, et al. Knockdown of HMGN2 increases the internalization of Klebsiella pneumoniaeby respiratory epithelial cells through the regulation of α5β1

integrin expression:[J]. Int J Mol Med. 2016; 38(3):737-746.

8.Xiong F, Liu K, Zhang F, et al. MiR-204 inhibits the proliferation and invasion of

renal cell carcinoma by inhibiting RAB22A expression. Oncol Rep. 2016; 35(5):3000-3008.

9.Xu G, Shi H, Ren L, et al. Enhancing the anti-colon cancer activity of quercetin by

self-assembled micelles. Int J Nanomedicine. 2015; 10:2051-2063.

10.Zheng S, Ren L, Li H, et al. High-mobility group nucleosome-binding domain 2

protein inhibits the invasion of Klebsiella pneumoniae into mouse lungs in vivo.

Mol Med Rep. 2015; 12(1):1279-85.

11.Shen X, Ren L, Teng Y, et al. Luteolin decreases the attachment, invasion and

cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation. Food Chem Toxicol. 2014; 72:204-11.

12.Xiang G, Deng X, Wei X, et al. Novel thermosensitive hydrogel for preventing formation of abdominal adhesions. Int J Nanomedicine. 2013; 8:2453-63.

13.Yang X, Huang N. Berberine induces selective apoptosis through the AMPK mediated mitochondrial/caspase pathway in hepatocellular carcinoma.

Mol Med Rep. 2013; 8(2):505-10.

14.Zheng F J, Shi L, Yang J, et al. Effect of tea polyphenols on the adhesion of highly metastatic human lung carcinoma cell lines to endothelial cells in vitro.[J].

Asian Pac J Cancer Prev. 2012; 13(8):3751-5.

15.Deng LX, Wu GX, Cao Y, et al. The chromosomal protein HMGN2 mediates

lipopolysaccharide-induced expression of β-defensins in A549 cells. FEBS J. 2011; 278(12):2152-66.

16.Cao Y, Wu G, Fan B, et al. High mobility group nucleosomal binding domain 2

protein protects bladder epithelial cells from Klebsiella pneumoniae invasion.

Biol Pharm Bull. 2011; 34(7):1065-71.

17.Deng L, Pan X Y, Wang L, et al. Hemoglobin and its derived peptides may

play a role in the antibacterial mechanism of the vagina. Hum Reprod. 2009; 24(1):211-8.

18.Li M, Pan X, Li Y, et al. Purification of antimicrobial factors from

human cervical mucus. Hum Reprod. 2007; 22(7):1810-5.