李婧瑜，副教授，硕士研究生导师

2013年6月于南开大学和哈佛医学院联合培养博士毕业，同年9月入职澳门尼威斯人网站8311病理生理学教研室。主持国家自然科学基金1项、省部级基金1项，其他科研基金2项；承担本科生和留学生多层次的病理生理学、机能实验学、基础医学英语及医学汉语，硕、博研究生的发病机制等课程教学工作。以第一/共同第一作者或共同通讯作者在 Nature Index 收录期刊 Immunity (IF: 22.553)、Journal of Biological Chemistry (IF: 4.238)等国际学术刊物发表SCI论文10篇，参编病理生理学和机能实验学等教材。曾获澳门尼威斯人网站8311“优秀青年人才”“青年骨干教师奖励计划”“优秀青年学者基金”等奖励。

主要研究方向

氧化应激与天然免疫的研究：

（1）氧化应激与蛋白翻译后修饰

（2）天然免疫反应的信号通路及调控机制

（3）炎症相关疾病的发病机制

联系方式

邮箱：jingyuli@scu.edu.cn

通讯地址：四川省成都市人民南路三段17号澳门尼威斯人网站8311华西校区基础医学与法医学院，病理生理学教研室

代表性论著（^#共同第一作者，*共同通讯作者）

1. Yuanyuan You^#, Junli Chen^#, Feimei Zhu, Qian Xu, Lu Han, Xiang Gao, Xiaoyu Zhang, Hongbo R. Luo, Junming Miao, Xiaodong Sun, Hongyu Ren, Yu Du, Lijuan Guo, Xiaoying Wang, Yi Wang, Shanze Chen, Ning Huang*,Jingyu Li*; Glutaredoxin 1 up-regulates deglutathionylation of α4 integrin and thereby restricts neutrophil mobilization from bone marrow;Journal of Biological Chemistry, 2019, 294(8): 2616-2627.

2. Jia-Chuan Li, Xiao-fei Shen, Jun-Ao Shao, Meng-Min Tao, Jian Gu,Jingyu Li*, Ning Huang*; The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats;Drug Design, Development and Therapy, 2018, 12: 2695-2706.

3. Heng Li, Xiao-fei Shen, Xin-e Zhou, Yan-e Shi, Lu-xia Deng, Yi Ma, Xiao-ying Wang,Jing-yu Li*, Ning Huang*;The antibacterial mechanism of high-mobility group nucleosomal binding domain 2 (HMGN2) on thegram-negative bacteria Escherichia coli,Journal of Zhejiang University-Science B, 2017, 18(5):410-420.

4. Xiao-Fei Shen^#, Yan Teng^#, Kai-Hui Sha, Xin-Yuan Wang, Xiao-Long Yang, Lai-Bin Ren, Xiao-Ying Wang,Jingyu Li*, Ning Huang*; Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder;Biofactors, 2016, 42(6): 674-685.

5. Kaihui Sha, Xiaofei Shen, Keyun Liu, Xiaolong Yang, Yan Teng, Xiaojuan Guo, Xinyuan Wang, Junming Miao, Hanwen Tian, Guangya Xu, Fumei Zhang, Feng Xiong, Xiaoying Wang, Junli Chen, Yi Wang,Jingyu Li*, Ning Huang*;Knockdown of high-mobility group nucleosome-binding protein 2 increases uropathogenic Escherichia coli invasion in human bladder epithelial cells through promoting actin cytoskeleton polymerization;International Journal of Clinical and Experimental Pathology, 2016;9(3):2970-2979.

6. Xiao-fei Shen, Lai-bin Ren, Yan Teng, Shuang Zheng, Xiao-long Yang, Xiao-juan Guo, Xin-yuan Wang, Kai-hui Sha, Na Li, Guang-ya Xu, Han-wen Tian, Xiao-ying Wang, Xiao-kang Liu,Jingyu Li*, Ning Huang*; Luteolin decreases the attachment, invasion and cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation;Food and Chemical Toxicology, 2014, 72: 204-211.

7. Fan Zhao^#,Jingyu Li^#, Ning Zhou, Jiro Sakai, Yuan Gao, Junfeng Shi, Bronia Goldman, Hayley M. Browdy, Hongbo R. Luo, and Bing Xu; De novo chemoattractants form supramolecular hydrogels for immunomodulating neutrophils in vivo;Bioconjugate Chemistry, 2014, 25(12):2116-2122.

8.Jiro Sakai^#,Jingyu Li^#, Kulandayan K. Subramanian^#, Subhanjan Mondal, Besnik Bajrami, Hidenori Hattori, Yonghui Jia, Bryan C. Dickinson, Jia Zhong, Keqiang Ye, Christopher J. Chang, Ye-Shih Ho, Jun Zhou, Hongbo R. Luo; Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils;Immunity, 2012, 37(6): 1037-1049.

9.Jingyu Li^#, Xiaodong Sun^#, Zaizhu Wang, Li Chen, Dengwen Li, Jun Zhou, Min Liu; Regulation of vascular endothelial cell polarization and migration by Hsp70/Hsp90-organizing protein;PLoS One, 2012, 7(4):e36389.

10. Fan Zhao,Jingyu Li, Hongbo R. Luo, Bing Xu;Supramolecular hydrogel of fMLF-based molecules and use thereof;US patent: US 10,232,037 B2;2019-03-19.