周黎明，女, 53岁，博士；教授/博士生导师；主要研究方向为：抗菌及抗肿瘤药物作用及耐药机理的研究,中药药理研究及新药开发； 澳门尼威斯人网站8311华西医学中心基础医学与法医学院药理教研室

一、主要简历

2006年05月——现在 澳门尼威斯人网站8311华西医学中心药理教研室教授、教研室主任

2002年09月——2006年5月 澳门尼威斯人网站8311华西医学中心药理教研室在职博士，副教授，教研室主任

1998年12月——2001年4月 哈佛大学医学院（美国波士顿）访问学者

1994年06月——1991年09月 华西医科大学药理教研室 讲师

1994年06月——1991年09月 硕士研究生学习（在职） 讲师

1985年08月——1991年08月 华西医科大学药理教研室 助教

1980年09月——1985年07月 华西医科大学医学系 读大学

二、近年发表文章：

1.Yi-ying Wu, Ling Zhu, Li-ming Zhou，The anti-proliferation effect of Aikete injection on hepatocellular carcinoma in vitro and in vivo，pharmaceutical biology,2011,495(5)531-53 (IF=1.65)

2 Jian Chen, Wen-bi Xiong, Yao Xiong,Yi-ying Wu, Xia-jing Chen, Zheng-jun Shao, Liming zhou, Calycosin Stimulates Proliferation of Estrogen Receptor-positive Human Breast Cancer Cells through Down Regulation of Bax gene expression and Up Regulation of Bcl-2 gene expression at Low Concentrations. Journal of Parenteral and Enteral Nutrition 2011 ;35(6):763-9.

3 Jian Chen , Litao Liu , Ruanling Hou , Zhenjun Shao , Yiying Wu, Xiajing Chen Liming Zhou，Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo，Cancer Letters 308 (2011) 144–151(IF=4.8)

4 Jianlei Zhaog,, Jian Chen,, Wenfu Tang , Lihong Wan , Wenbi Xiong and Liming Zhou，Efect of Da-Cheng-Qi decoction on pancreatitis-associated lung injury in patients and anti-infammatory responses in rat models，Pharmaceutical Biology，2011, 49（10）: 1058–1064.

5 Shao Zhen-Jun, Zheng Xiao-Wei, Feng Ting, Huang Juan, Chen Jian, Wu Yi-Ying, Zhou Li-Ming zhou, Tu Wen-Wei, Li Hong. Andrographolide exerted its antimicrobial effects by up-regulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells. Can J Physiol Pharmacol 2012 ; 90:647-653

6．Wu YY, Wan LH, Zheng XW, Shao ZJ, Chen J, Liu LT, Kuang WJ, Tan XS, Zhou LM. Inhibitory effects ofβ,β-Dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo. Phytother Res 2012; 26:764-771

7 Li-Hong Wan, Jian Chen, Liang Li2, Wen-Bi Xiong1, and Li-Ming Zhou Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats，Pharmaceutical Biology, 2011; 49(11): 1204–1209

8 Shao Zhen-Jun, Zhang Yuan-Yuan, Fan Ying-Ying, Jin Shao-Ju, Yan Jiao d, Zheng Xiao-Wei, Chen Jian, Xiong Yao, Zhou Li-Ming，b,b-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo Biochemical Pharmacology, 2012 (84) 507–512

9 Yao Xiong, Xiu Ying Ma, Ziran Zhang, Zhen Jun Shao, Yuan Yuan Zhang and Liming Zhou, Apoptosis induced by β,β-dimethylacrylshikonin is associated with Bcl-2 and NF-κB in human breast carcinoma MCF-7 cells. Oncology Letters 2013,6: 1789-1793

10. Li-Tao Liu, Li?Hong Wan, Xiao?Hong Song, Yao Xiong, Shao?Ju Jin , Li-Ming Zhou Relevance of class 1 integrons and extended?spectrum β-lactamases in drug resistant Escherichia coli. MOLECULAR Medicine Reorts 2013,8: 1251-1255,

11. Yuan-Yuan Zhang , Li-Ming Zhou Omentin-1,a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 de acetylation in hepatocellular carcinoma cells. European Journal of Pharmacology 2013,69: 8137–144

12. Xiuying Ma, Shaoju Jin, Yuanyuan Zhang, Lihong Wan, Yanyan Zhao , Liming Zhou Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo Phytother. Res. 2014, 28: 560–567

13 Shaoju Jin, Yishuang Mu, Xiaodong Wang, Zhenru Liu, Lihong Wan 55.Yao Xiong, Yuanyuan Zhang, Li Li, Liming Zhou, Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma. Moleculor Biology Reports. 2014; 41(5):3393-9.

14.Yao Xiong, Yuan-Yuan Zhang, Yi-YingWu, Xiao-Dong Wang, Li-Hong Wan Li- Li , Li-Ming Zhou, Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages, Life Sciences, 106; 2014: 19–24

15．Wen-Bi Xiong, Zhen-Jun Shao?, Yao Xiong, Jian Chen, Yun Sun, Ling Zhu and Li-Ming Zhou Dehydroandrographolide enhances innate immunity of intestinal tract through up-regulation the expression of hBD-2，DARU Journal of Pharmaceutical Sciences，2015，23:（1）：1-7

16. Zhenru Liu, Baodong Ling, Liming Zhou，Prevalence of 16S rRNA methylase, modifying enzyme, and extended-spectrum beta-lactamase genes among Acinetobacter baumannii isolates Journal of Chemotherapy 2015，27（4）：207-212

17. Zhen-Ru Liu , Yi Song, Li-Hong Wan, Yuan-Yuan Zhang , Li-Mimg Zhou，Over-expression of miR-451a can enhance the sensitivity of breast cancer

cells to tamoxifen by regulating 14-3-3ζ, estrogen receptorα,and autophagy，Life Sciences 149 (2016) 104-113

三、近年编写教材情况：

1．编委：医学八年制教材《药理学》，人民卫生出版社，2015年出版

2．副主编：国家级规划教材《药理学（第4版），科学出版社，2016年出版

3. .编委：普通高等教育“十一五”国家级规划教材《药理学》，第8版，人民卫生出版社，2013年出版。（1979年第一版）

4.全国高等院校器官-系统整合教材《血液与肿瘤》，人民卫生出版社，2016年出版

四、主要学术兼职：

1． 中国药理学会理事

2． 中国药理学会化疗药理专业委员会委员主任委员

3． 中国药理学会中药药理专业委员会委员

4． 四川生理科学杂志主编

5． 四川生理科学会副理事长

6． 四川省药学会药理专业委员会委员