张舒羽教授

张舒羽，教授、博士生导师，学院副院长，放射医学研究室主任，国家卫生健康委员核技术医学转化重点实验室首席科学家。长期从事肿瘤放射敏感性机制及核辐射损伤防治策略研究。主持国家自然科学基金项目5项，省部级项目6项。发表SCI论文100余篇，第一作者或通讯作者论文50余篇。2015年获得国家自然科学基金委优秀青年科学基金；先后入选中国核工业集团（原核工业部）青年英才、四川省高层次人才计划、四川省技术和学术带头人和四川省杰出青年科技人才。担任 Front Oncol、Exp Ther Med、中华放射医学和防护杂志、国际放射医学核医学杂志和澳门尼威斯人网站8311学报（医学版）等期刊编委。担任教育部科技奖励、国家自然科学基金优青、面上及青年基金项目等评审专家。获得中国发明专利15件，美国发明专利3件；主编专著2部。指导学生获得“互联网+”大学生创新创业大赛省赛金奖、全国总决赛银奖。研究成果为首或为主获教育部二等奖、中国辐射防护学会二等奖、四川省教学成果一等奖等奖励。

代表性论文：（*通讯作者）

1.Liu P, Yu D, Sheng W, Geng F, Zhang J*, Zhang S*. PPARα activation by fenofibrate ameliorates radiation‐induced skin injury.J Eur Acad Dermatol Venereol. 2022;36(3):e207-e210.

2.Yu D*, Zhang S, Mo W, Jiang Z, Wang M, An L, Wang Y, Liu Y, Jiang S, Wu A, Cao J, Zhang S*. Transplantation of the Stromal Vascular Fraction (SVF) Mitigates Severe Radiation-Induced Skin Injury.Radiat Res. 2021;196(3):250-260.

3. Feng Y, Feng Y, Gu L, Liu P, Cao J, Zhang S*. The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil.Front Oncol. 2021;11:720632.

4. Qiu Y, Gao Y, Yu D, Zhong L, Cai W, Ji J, Geng F, Tang G, Zhang H, Cao J, Zhang J*,Zhang S*. Genome-wide analysis reveals zinc transporter ZIP9 regulated by DNA methylation promotes radiation-induced skin fibrosis via the TGF-β signaling pathway.J Invest Dermatol. 2020;140:94-102.

5. Xiao Y, Mo W, Jia H, Yu D, Qiu Y, Jiao Y, Zhu W, Koide H, Cao J*,Zhang S*. Ionizing radiation induces cutaneous lipid remolding and skin adipocytes confer protection against radiation-induced skin injury.J Dermatol Sci. 2020;97(2):152-160.

6. Cao J, Zhu W, Yu D, Pan L, Zhong L, Xiao Y, Gao Y, Jiao Y, Zhang Q, Ji J, Yang H,Zhang S*, Cao J*. The Involvement of SDF-1α/CXCR4 Axis in Radiation-Induced Acute Injury and Fibrosis of Skin.Radiat Res. 2019;192(4):410-421.

7.Gu C, Luo J, Lu X, Tang Y, Ma Y, Yun Y, Cao J, Cao J, Huang Z, Zhou X*,Zhang S*. REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.Cancer Sci. 2019;110(3):962-972.

8.Xue J, Zhu W, Song J, Jiao Y, Luo J, Yu C, Zhou J, Wu J, Chen M, Ding WQ, Cao J*,Zhang S*. Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway.Oncogene. 2018;37(7):953-962.

9. Xue J, Yu C, Sheng W, Zhu W, Luo J, Zhang Q, Yang H, Cao H, Wang W, Zhou J, Wu J, Cao P, Chen M, Ding WQ, Cao J*,Zhang S*. The Nrf2/GCH1/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade.J Invest Dermatol. 2017;137(10):2059–2068.

10. Nie J, Zhang J, Wang L, Lu L, Yuan Q, An F,Zhang S*, Jiao Y*. Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4.J Exp Clin Cancer Res. 2017;36(1):183.

11. Wang W, Luo J, Sheng W, Xue J, Li M, Ji J, Liu P, Zhang X, Cao J,Zhang S*. Proteomic profiling of radiation-induced skin fibrosis in rats: targeting the ubiquitin-proteasome system.Int J Radiat Oncol*Biol*Phys.2016;95(2):751-60.

12. Tang Y, Cui Y, Li Z, Jiao Z, Zhang Y, He Y, Cheng G, Zhou Q, Wang W, Zhou X, Luo J*,Zhang S*. Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells.J Exp Clin Cancer Res. 2016;35(1):7.

13.Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ*. The superoxide dismutase 1 (SOD1) 3'UTR maintains High expression of the SOD1 gene in cancer cells: The involvement of the RNA binding protein AUF1.Free Radic Biol Med.2015,85:33-44.

14.Zhang S*, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J*, Zhou J, Wu J, Ding WQ. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 (PRDX-6) against ionizing radiation.Free Radical Biol & Med. 2014;69:96-107.

15.Zhang S, Chen H, Zhao S, Cao J, Tong J, Lu J, Wu W, Shen H, Wei Q, Lu D*. REV3L 3’UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility.Oncogene.2013:10;32(2):242-50.

16.Zhang S*, Hao J, Xie F, Hu X, Liu C, Tong J, Zhou J, Wu J, Shao C*. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.Carcinogenesis. 2011;32(8):1183-9.

17.Zhang S, Lu J, Zhao X, Wu W, Wang H, Lu J, Wu Q, Chen X, Fan W, Wang F, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D*.A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.Carcinogenesis. 2010;31:2151-2158.

实验室欢迎即将入学或保送的博士生和硕士生报考，也欢迎博士后和本科生加盟，在学术探索中共同进步。

联系方式：zhangshuyu@scu.edu.cn、zhang.shuyu@hotmail.com