姓名：谢娜

职称：副研究员

【简历】

2014年在澳门尼威斯人网站8311生物治疗国家重点实验室获博士学位，随后在澳门尼威斯人网站8311华西医院从事博士后研究，2015-2019年南加州大学访问学者，2019年至今任98858vip威尼斯下载副研究员。主要从事病毒诱导肿瘤发生发展过程中的相互作用调控网络、氧化应激、代谢调控和细胞自噬等研究。作为课题负责人承担国家自然科学基金面上项目、青年科学基金等项目；作为课题骨干参与国家重大科学研究计划（973计划）、国家重点研发计划、国家自然科学基金重大项目及重点项目等。以第一/共同第一作者或共同通讯作者在Autophagy、Signal Transduct Target Ther、Carcinogenesis、Theranostics、Expert Rev Proteomics、J Proteomics等国际学术期刊发表10余篇学术论文，被包括Cell、Nat Rev Drug Discov、Nat Rev Microbiol等在内的国际学术期刊引用1100余次。

【研究方向】

1. 氧化应激与肿瘤发生发展

2. 病毒诱导肿瘤发生发展的机制研究

【联系方式】

邮箱：xnshina@126.com（常用）；naxie@scu.edu.cn

【代表性论著】(*共同第一作者；^#共同通讯作者)

1. Wu P*, Gao W*, Su M, Nice EC, Zhang W, Lin J^#,Xie N^#. Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment.Front Cell Dev Biol. 2021; 9: 357.（通讯作者）

2. Xie N*, Zhang L*, Gao W*, Huang C, Huber PE, Zhou X, Li C^#, Shen G^#, Zou B^#. NAD⁺ metabolism: pathophysiologic mechanisms and therapeutic potential.Signal Transduct Target Ther. 2020;5(1):227.

3. Peng L, Jiang J, Tang B, Nice EC, Zhang YY^#,Xie N^#. Managing therapeutic resistance in breast cancer: from the lncRNAs perspective.Theranostics. 2020; 10(23):10360-77.（通讯作者）

4. Zhang Z*, Zhou L*, Xie N*, Nice EC, Zhang T, Cui Y, Huang C. Overcoming cancer therapeutic bottleneck by drug repurposing.Signal Transduct Target Ther. 2020;5(1):113.（并列第一作者）

5. Wang K, Chen Y, Zhang P, Lin P,Xie N^#, Wu M^#. Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases.Cells. 2019; 8(2). pii: E123. (并列通讯)

6. Xie N, Yuan K, Zhou L, Wang K, Chen HN, Lei Y, Lan J, Pu Q, Gao W, Zhang L, Shen G, Li Q, Xiao H, Tang H, Xiang R, He M, Feng P, Nice EC, Wei Y, Zhang H, Yang J, Huang C. PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation.Autophagy. 2016; 12(9): 1507-20.

7. Xie N*, Huang K*, Zhang T, Lei Y, Liu R, Wang K, Zhou S, Li J, Wu J, Wu H, Deng C, Zhao X, Nice EC, Huang C. Comprehensive proteomic analysis of host cell lipid rafts modified by HBV infection.J Proteomics. 2012; 75(3):725-39.

8. Xie N*, Chen X*, Zhang T, Liu B, Huang C. Using proteomics to identify the HBx interactome in hepatitis B virus: how can this inform the clinic?Expert Rev Proteomics. 2014; 11(1):59-74.

9. Xie N*, Huang K, Lei Y, Ran Y, Huang C. Proteomics annotation of lipid rafts modified by virus infection.Comb Chem High Throughput Screen. 2012; 15(3):253-65.

10. Wu J*,Xie N*, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C, Wei Y. GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.Carcinogenesis. 2013; 34(12):2861-9.（并列第一作者）

11. Zhang T*,Xie N*, He W, Liu R, Lei Y, Chen Y, Tang H, Liu B, Huang C, Wei Y. An integrated proteomics and bioinformatics analyses of hepatitis B virus X interacting proteins and identification of a novel interactor apoA-I.J Proteomics. 2013; 84:92-105.（并列第一作者）

12. Wu J*,Xie N*, Zhao X, Nice EC, Huang C. Dissection of aberrant GPCR signaling in tumorigenesis--a systems biology approach.Cancer Genomics Proteomics. 2012; 9(1):37-50.（并列第一作者）